Directory of registries

Terminated clinical registry of patients who underwent autologous stem cell transplantation and who were treated with plerixafor.

start of the project: July 2011

end of the project: December 2017

Plerixafor is an immunostimulant used to mobilise haematopoietic stem cells in cancer patients. The stem cells are subsequently transplanted back to the patient. Peripheral blood stem cell mobilisation, which is important as a source of haematopoietic stem cells for transplantation, is generally performed using granulocyte colony-stimulating factor (G-CSF), but is ineffective in around 15 to 20% of patients. Combination of G-CSF with plerixafor increases the percentage of persons that respond to the therapy and produce enough stem cells for transplantation.

The Simplify project belongs to a group of projects solved in cooperation between the Institute of Biostatistics and Analyses and the CELL group. IBA MU provided the technical solution of the registry and data analysis.

  • Expert guarantors: Prof. Jiří Mayer, MD, PhD; Prof. Zdeněk Ráčil, MD, PhD
  • Partners: large haemato-oncological centres in the Czech Republic